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Titlebook: Innovative Antimetabolites in Solid Tumours; Matti S. Aapro Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Antimetabol

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978-3-642-79202-1Springer-Verlag Berlin Heidelberg 1994
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Introduction,lmost half a century has elapsed since Farber published the demonstration of efficacy of aminopterin in childhood acute leukaemia. Maybe antimetabolites should be called the “aspirin” of oncology, as they share a long-standing history and are continuously rediscovered as a class of agents.
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Thymidylate Synthase Inhibitors, Modulation of 5-Fluorouracil and Folate Analogues,to clinical practice. The effects of 5-fluorouracil on the cell are 1) inhibition of thymidylate synthase, 2) a direct effect on DNA, and 3) a direct effect on RNA [1]. These mechanisms and their modulation by other factors designed to increase activation, response rates and survival, will be discussed in this chapter.
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Chemotherapy in Advanced Non-Small Cell Lung Cancer. Changes in Performance Status and Tumour-Relatalistic possibility of increasing survival. The problem is that relatively few active agents have been identified. Many earlier studies also involved combinations of drugs with minimal antitumour effect. It is not surprising therefore that chemotherapy of NSCLC was and still is considered by some to be of little or of no value.
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Conference proceedings 1994erapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been
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nt chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been978-3-642-79202-1978-3-642-79200-7
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Peter Harper,Hilary Calvertersuchen zeigte, bei weitem die wichtigste Bedeutung für das Zustandekommen dieser Blutverschiebungen im Körper haben, so war es doch von großem Wert, die Ergebnisse der Anwendung der Methode des „inneren Plethysmographen“ durch Benutzung einer ganz anderen Untersuchungsart kontrollieren zu können.
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Distinguishing Artifactual Fatty Acid Dimers from Fatty Acid Esters of Hydroxy Fatty Acids in Untargpplying liquid chromatography (LC) and mass spectrometry (MS)-based methods are widely used to survey a broad range of metabolites within various metabolic pathways, including organic acids, amino acids, nucleosides, and lipids. Accurate and complete identification of putative metabolites is an ongo
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