Titlebook: Innate Immunity; Jonathan Ewbank,Eric Vivier Book 2008 Humana Press 2008 CMV.Chromosom.Immune System.Immunity.Macrophages.Malaria.Vivo.gen

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Antoine Giraudeed for tools to understand output from clustering algorithms. We developed a new visual interface to meet this demand. Our interface helps non-technical users understand documents and clusters in massive databases (e.g., document content, cluster sizes, distances between clusters, similarities of d

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ENU Mutagenesis in Mice,om germline mutagenesis has become an efficient means by which to find the function of yet undescribed genes. In this chapter, we will provide a practical guideline for performing germline mutagenesis in mice. In particular, we will focus on the application of this technology to identify genes that

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Innate Immunity Genes as Candidate Genes,mplex diseases. In particular, few genes involved in complex diseases related to immune response, such as infectious diseases and inflammatory diseases, have been identified. Recent advances in genotyping technology lead to the depository of millions of single-nucleotide polymorphisms (SNPs) into pu

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KIR Genotyping and Analysis, time due in large part to unequal crossing over. Consequently, individuals exhibit considerable haplotypic variation in terms of gene content. The highly polymorphic human leukocyte antigen (HLA) class I loci encode ligands for the KIR; thus, it is not surprising that . genes also show significant

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Experimental Model for the Study of the Human Immune System,ich mouse models have been proven extremely efficient and handy. Recent advances have lead to the establishment of new models with improved characteristics, both in terms of engraftment efficiency and in situ multilineage human hematopoietic development. In particular, the use of newborn BALB/c Rag2

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Bacterial Artificial Chromosome Transgenesis Through Pronuclear Injection of Fertilized Mouse OocytBacterial artificial chromosomes (BACs) are large enough to encompass the natural context of most mammalian genes and consequently deliver more reliable recapitulations of their endogenous counterparts. Furthermore, recombineering methods now make it easy to engineer precise changes in a BAC transge