Titlebook: Inhibitors of Protein Kinases and Protein Phosphates; Lorenzo A. Pinna,Patricia T.W. Cohen (Professor of Book 2005 Springer-Verlag Berlin

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Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimusll activation, ciclosporin, dramatically improved the results of renal transplantation and transformed other types of organ transplantation from experimental to standard therapy. The discovery of a second drug, tacrolimus, that was structurally unrelated to ciclosporin but which had an identical mec

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Clinical Aspects of Imatinib Therapyrosine kinase in chronic myeloid leukemia, this was the first disease selected for clinical trials with imatinib. In the clinical trials, patients in all phases of the disease responded to imatinib and experienced minimal toxicity. Responses in patients with chronic phase disease have been durable,

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Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Gronesis, and tumour resistance to chemotherapy and radiotherapy. This chapter describes a low-molecular- weight EGFR tyrosine kinase inhibitor (EGFR-TKI), Iressa (gefitinib, ZD1839). Iressa is a potent EGFR-TKI which blocks EGF-stimulated EGFR autophosphorylation in tumour cells and selectively inhibi

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S. Kumar,S. M. Blakeußt bereits der junge Schumann von der historischen Bedeutung der „romantischen“ Musik seit Beethoven gesprochen hat. 1834, etwa zur Zeit als er aus Wilhelm Christian Müllers „Aesthetisch-historischen Einleitungen in die Wissenschaft der Tonkunst“ Daten zur Musikgeschichte exzerpierte,. kündigte Sch

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M. Gaßel,C. Breitenlechner,S. Herrero,R. Engh,D. Bossemeyernschauung entsprechend, eigentlich mit einer Betrachtung der Schriften Wilhelm Heinrich Wackenroders und Ludwig Tiecks sowie E. T. A. Hoffmanns beginnen. Der Begriff läßt sich aber weder in den „Herzensergießungen eines kunstliebenden Klosterbruders” (1797) noch in den „Phantasien über die Kunst, fü

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