| 书目名称 | Information-Theoretic Evaluation for Computational Biomedical Ontologies |
| 编辑 | Wyatt Travis Clark |
| 视频video | |
| 概述 | Provides a concise overview of a proven method for evaluating the performance of computational protein-function prediction.Proposes a solution that is critical in disease-gene prioritisation, an incre |
| 丛书名称 | SpringerBriefs in Computer Science |
| 图书封面 |  |
| 描述 | The development of effective methods for the prediction of ontological annotations is an important goal in computational biology, yet evaluating their performance is difficult due to problems caused by the structure of biomedical ontologies and incomplete annotations of genes. This work proposes an information-theoretic framework to evaluate the performance of computational protein function prediction. A Bayesian network is used, structured according to the underlying ontology, to model the prior probability of a protein‘s function. The concepts of misinformation and remaining uncertainty are then defined, that can be seen as analogs of precision and recall. Finally, semantic distance is proposed as a single statistic for ranking classification models. The approach is evaluated by analyzing three protein function predictors of gene ontology terms. The work addresses several weaknesses of current metrics, and provides valuable insights into the performance of protein function prediction tools. |
| 出版日期 | Book 2014 |
| 关键词 | Algorithm Development; Information Theory; Ontology; Protein Function Prediction; Semantic Evaluation; al |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-04138-4 |
| isbn_softcover | 978-3-319-04137-7 |
| isbn_ebook | 978-3-319-04138-4Series ISSN 2191-5768 Series E-ISSN 2191-5776 |
| issn_series | 2191-5768 |
| copyright | The Author(s) 2014 |
发表于 2025-3-21 19:51:27
