Titlebook: Inflammatory Disorders of the Nervous System; Pathogenesis, Immuno Alireza Minagar,J. Steven Alexander Book 20051st edition Humana Press 20

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Multiple Sclerosis,er to Cruveillier, the famed professor of anatomy. Although others also described the pathological anatomy of the disease in remarkable detail, it was Charcot who characterized the clinical illness and correlated the illness with its unique neuropathology (.). From the outset, researchers recognized

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Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis,immune disease (.,.). Although the etiology of MS is unknown, most investigators believe that the immune system is intimately involved in the progression of the disease (.). MS is clinically associated with periods of disability (relapse) alternating with periods of recovery (.) but often leading to

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Neuromyelitis Optica,verse myelitis (TM), optic neuritis (ON), recurrent forms of TM and ON, the Marburg variant of MS, Balo’s concentric sclerosis, and neuromyelitis optica (NMO; Devic’s syndrome or Devic’s disease) (.). The association of spinal cord disease and visual impairment was first recognized in 1870 by Allbut

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Transverse Myelitis,per year (.). TM is characterized by focal inflammation within the spinal cord and clinical manifestations are caused by resultant neural dysfunction of motor, sensory, and autonomic pathways within and passing through the inflamed area. There is often a clearly defined rostral border of sensory dys

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Central Nervous System Vasculitis,tural damage to vessels, and usually vascular necrosis. Because involvement of blood vessels can result from inflammation of any type, vasculitis may be a presentation of diverse disorders. Vasculitis can occur either as a primary vasculitic disease or secondarily to another underlying pathology (.–

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Neuropsychiatric SLE,estimated prevalence of 130 per 100,000 people in the United States (.). Thus, about 380,000 Americans have SLE. Women are affected nine times more frequently than men (.). African Americans and Hispanics are affected much more frequently than Euro-Americans and have more disease morbidity (.–.). Al