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Titlebook: Inflammation and Angiogenesis; Domenico Ribatti Book 2017 Springer International Publishing AG 2017 Inflammation.Angiogenesis.Immnune cell

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发表于 2025-3-21 19:36:03 | 显示全部楼层 |阅读模式
书目名称Inflammation and Angiogenesis
编辑Domenico Ribatti
视频video
概述Inflammatory infiltrate is a hallmark of tumors and chronic inflammatory processes.Inflammatory cells are able to secrete a large array of angiogenic molecules.Anti-angiogenic properties of immune cel
图书封面Titlebook: Inflammation and Angiogenesis;  Domenico Ribatti Book 2017 Springer International Publishing AG 2017 Inflammation.Angiogenesis.Immnune cell
描述This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information
出版日期Book 2017
关键词Inflammation; Angiogenesis; Immnune cells; tumor growth; Cancer
版次1
doihttps://doi.org/10.1007/978-3-319-68448-2
isbn_softcover978-3-319-88604-6
isbn_ebook978-3-319-68448-2
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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发表于 2025-3-21 23:12:07 | 显示全部楼层
Domenico RibattiInflammatory infiltrate is a hallmark of tumors and chronic inflammatory processes.Inflammatory cells are able to secrete a large array of angiogenic molecules.Anti-angiogenic properties of immune cel
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Immune Cells,Immune cells can be divided into innate (myeloid) and adaptive (lymphoid) cells. Innate immune cells, including macrophages, polymorphonuclear granulocytes (neutrophils, basophils and eosinophils) mast cells, dendritic cells, natural killer cells and platelets represent the first line of defence against pathogens and foreign agents (Table 3.1).
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Inflammation and Angiogenesis,ory reactions, immune cells synthesize and secrete pro-angiogenic factors that promote neovascularization. Among the cytokines, IL-6, TNF-α and CXCR2 chemokine receptor and its ligand promote angiogenesis in tumor microenvironment.
发表于 2025-3-22 22:30:01 | 显示全部楼层
The Contribution of Immune Cells to Angiogenesis in Inflammation and Tumor Growth, during the earliest phases of inflammatory processes. Neutrophils are considered as macrophages, i.e. capable to phagocyte small particles such as bacteria, viruses, and small pieces of cell debris. Similarly to TAMs, tumor associated neutrophils (TANs) can exert both anti-tumoral and pro-tumoral functions (Fig. 7.1) (Fridlender et al. 2009).
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The Importance of Microenvironment in Tumor Metastasis,to suggest that interactions between tumor cells and host cells in the microenvironment are critical in regulating tumorigenesis (Paget 1889). Certain favored tumor cells (the ‘seed’), he said, had a specific affinity for the growth-enhancing milieu within specific organs (the ‘soil’), and hence met
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