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Titlebook: Infective Endocarditis and Other Intravascular Infections; Lawrence R. Freedman Book 1982 Springer Science+Business Media New York 1982 an

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Establishment of Intravascular Infection,ations. This mechanism is easily demonstrable in animals, and there is no evidence to support the older suggestion that bacteria arrive in the vegetations by way of the blood supply to the valve or endocardium. Studies of the early vegetations show clearly that colonization takes place from the edge
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Treatment,tituting effective antibiotic therapy for intravascular infection at the earliest possible moment. In most analyses of series of patients with infective endocarditis (IE), those patients treated for the presumption of IE in the absence of a positive blood culture had higher mortality rates than thos
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Indices of Effectiveness of Treatment,on of temperature, in which case they might feel very much better quickly. On the other hand, although fever usually does subside within 2–4 days, this subsidence is gradual, and dramatic response is not the rule. Persistence of fever may indicate ineffective antibiotic therapy or a drug reaction. I
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Outcome of Treatment, a high mortality. How high depends on the location of the infection, the nature of the infecting microorganism, and the expertness with which the major cause of death, valve destruction, is recognized and treated surgically.
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