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Titlebook: Infectious Causes of Cancer; Targets for Interven James J. Goedert (Chief) Book 2000 Springer Science+Business Media New York 2000 Carcinom

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Overview of Herpesviruseserent members of the . family are indistinguishable and consist of four distinct components: the core, capsid, tegument, and envelope (Fig. 1) .. The core contains a double-stranded DNA genome arranged in an unusual torus shape that is located inside an icosadeltahedral capsid that is approx 100 nm
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X-Linked Lymphoproliferative Disease the mutated gene central to this condition has been cloned and studies are underway to elucidate its normal immunologic function. This review summarizes our present state of knowledge of X-linked lymphoproliferative disease (XLP).
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Posttransplant Lymphoproliferative Disorderion of immunosuppression. Similar if not identical EBV-associated B-cell proliferations have since been described in congenital and in other acquired immunodeficiency states. Although the initial events in the course of viral lymphomagenesis appear to be unique to the setting of immunodeficiency, th
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Hodgkin’s Diseaseeed–Sternberg cells by multiple researchers between 1878 and 1902. The Lukes & Butler, Rye, and REAL classifications of HD were devised in the 1960s, 1980s, and 1990s, respectively. Yet, despite our longstanding ability to identify HD, the etiology of the disease has remained obscure.
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Leiomyoma and Leiomyosarcomathe increased frequency of smooth muscle cell tumors in immunocompromised persons, and the unexpected association of these tumors with Epstein-Barr virus (EBV) infection of smooth muscle cells. In 1965, Nobel laureate Sir MacFarlane Burnet emphasized the critical role of immunosurveillance in limiti
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Kaposi’s Sarcoma and Other HHV-8 Associated Tumorss. This was the first patient we had seen who was infected with the human immunodeficiency virus (HIV), and he had Kaposi’s sarcoma (KS). We never imagined then that 10 yr later most patients at this hospital, as in many other South African hospitals, would have AIDS-related illnesses. One in eight
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Retroviruses and CancerNeoplasia may result from the direct infection and transformation of the precursor tumor cell by the retrovirus, as is evident in adult T-cell leukemia caused by the human T-cell lymphotropic virus type I (HTLV-I) (. Chapter 12). Neoplasia may also develop as an indirect consequence of retrovirus in
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