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Titlebook: Inducible Enzymes in the Inflammatory Response; Derek A. Willoughby,Annette Tomlinson Book 1999 Springer Basel AG 1999 clinic.enzyme.infla

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书目名称Inducible Enzymes in the Inflammatory Response
编辑Derek A. Willoughby,Annette Tomlinson
视频video
丛书名称Progress in Inflammation Research
图书封面Titlebook: Inducible Enzymes in the Inflammatory Response;  Derek A. Willoughby,Annette Tomlinson Book 1999 Springer Basel AG 1999 clinic.enzyme.infla
描述This volume will be of great value to all those researchers in the area of the inflam­ matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta­ minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat­ ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician‘s armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are
出版日期Book 1999
关键词clinic; enzyme; inflammation; research; rheumatism
版次1
doihttps://doi.org/10.1007/978-3-0348-8747-2
isbn_softcover978-3-0348-9755-6
isbn_ebook978-3-0348-8747-2Series ISSN 1422-7746 Series E-ISSN 2296-4525
issn_series 1422-7746
copyrightSpringer Basel AG 1999
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Overview of COX-2 in inflammation: from the biology to the clinic,hospholipids (principally, arachidonic acid) into prostanoids (prostaglandins and thromboxanes). Prostanoids contribute to diverse physiological and pathological processes including inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs), the prototype of which is aspirin, owe their therapeutic
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Overview of HO-1 in inflammatory pathologies,ld in the centre of the molecule by four nitrogen atoms. This molecule is of fundamental importance in many biochemical pathways including oxygen transport by hemoglobin and electron transport in the respiratory chain. Heme is also a prosthetic group for numerous enzymes, which most notably in the c
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Inducible enzymes In the pathogenesis of rheumatoid arthritis,approximately 2–3% and, on average, accounts for the loss of 88 million working days per year. Thus, chronic inflammatory diseases like RA impose a considerable financial burden on national economies. Intervention therapy tends merely to limit inflammation and may induce adverse reactions but, in ge
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