| 书目名称 | Induced Pluripotent Stem Cells in Brain Diseases | | 副标题 | Understanding the Me | | 编辑 | Vivi M. Heine,Stephanie Dooves,Judith Wagner | | 视频video | | | 概述 | Up-to-date review on the latest reprogramming techniques.Comprehensive overview of the epigenetic models and how these will help us to map cell identity, plasticity and fate.Current state and issues o | | 丛书名称 | SpringerBriefs in Neuroscience | | 图书封面 |  | | 描述 | Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM). | | 出版日期 | Book 2012 | | 关键词 | epigenetics; induced pluripotent stem cell; neurology; regenerative medicine | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-007-2816-5 | | isbn_softcover | 978-94-007-2815-8 | | isbn_ebook | 978-94-007-2816-5Series ISSN 2191-558X Series E-ISSN 2191-5598 | | issn_series | 2191-558X | | copyright | The Author(s) 2012 |
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发表于 2025-3-21 18:53:18
