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Titlebook: Induced Pluripotent Stem Cells; Sibel Yildirim Book 2012 Author 2012 Pluripotent.Stem Cells.Yildirim

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发表于 2025-3-21 17:30:28 | 显示全部楼层 |阅读模式
书目名称Induced Pluripotent Stem Cells
编辑Sibel Yildirim
视频video
概述Focuses on selected topics.Includes supplementary material:
丛书名称SpringerBriefs in Stem Cells
图书封面Titlebook: Induced Pluripotent Stem Cells;  Sibel Yildirim Book 2012 Author 2012 Pluripotent.Stem Cells.Yildirim
描述Induced Pluripotent Stem (iPS) cells are mature cells that have been genetically reprogrammed so that they return to their embryonic state. It is not yet known if iPS stem cells and embryonic stem cells differ significantly. Today many fundamental belief systems in biology are shifting towards accepting that mature body cells can be reverted to an embryonic state without the help of eggs or embryos. With their changed identities, iPS cells are then ready to serve as new tools for research in the fields of disease pathogenesis, drug discovery, oncology, and cell transplantation. One example of this would be using iPS from a patient’s mature cells to repair damaged tissue; it is thought that there would be very low incidence of rejection of the ‘new’ tissue in these cases. For the last four years, this therapeutic promise has been studied by hundreds of researchers worldwide in an effort to understand the ability of these cells to reverse their biological clocks.
出版日期Book 2012
关键词Pluripotent; Stem Cells; Yildirim
版次1
doihttps://doi.org/10.1007/978-1-4614-2206-8
isbn_softcover978-1-4614-2205-1
isbn_ebook978-1-4614-2206-8Series ISSN 2192-8118 Series E-ISSN 2192-8126
issn_series 2192-8118
copyrightAuthor 2012
The information of publication is updating

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2192-8118 reprogrammed so that they return to their embryonic state. It is not yet known if iPS stem cells and embryonic stem cells differ significantly. Today many fundamental belief systems in biology are shifting towards accepting that mature body cells can be reverted to an embryonic state without the he
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Modeling Disease in a Dish,utant human ESC lines as disease models since Thomson et al. derived human ESC lines in 1998. With the known disease-associated genetic loci and explicit disease phenotype, genetically modified human ESCs could help to cell replacement therapies and modeling human diseases.
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Pluripotent Cells,o counterparts of the ICM. Cells of the ICM do not self-renew, and they have globally hypomethylated genome, whereas, ESCs have unlimited proliferation potential and they have characteristically highly methylated genome.
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2192-8118 e has been studied by hundreds of researchers worldwide in an effort to understand the ability of these cells to reverse their biological clocks.978-1-4614-2205-1978-1-4614-2206-8Series ISSN 2192-8118 Series E-ISSN 2192-8126
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Challenges to Therapeutic Potential of hiPSCs,in vivo models. Moreover, to generate markers for differentiation and gene corrections, gene-targeting strategies are necessary. Besides, cell-type specific lineage reporters, lineage-tracking tools and tools to disrupt, repair, or overexpress genes should be developed in order to model many human d
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