Titlebook: Individual Susceptibility to Genotoxic Agents in the Human Population; Frederick J. Serres,Ronald W. Pero Book 1984 Plenum Press, New York

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Interindividual Differences in Monooxygenase Activities of Human Liverces suggests that at least some of these compounds can cause cancer in man [2]. It has recently been estimated that as much as 90% of cancer in man is environmental in origin, the vast majority of this due to chemicals [3]. The development of a neoplasm following exposure to a chemical carcinogen is

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Involvement of Prostaglandin Synthetase in the Metabolic Activation of Chemical Carcinogens — Phenacte . is arachidonic acid (AA). The PGS contains two activities. The fatty acid cyclooxygenase activity, catalyzes the oxygenation of arachidonic acid to a hydroperoxy endo- peroxide (PGG.), while the hydroperoxidase activity catalyzes the reduction of PGG. to a hydroxy endoperoxide (PGH.) [2–3]. PGH

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The Use of Immunological and Molecular Biological Techniques in the Assessment of Occupational and Esses. The occupational diseases do not differ biologically from other, non-occupationally-induced diseases, but are unique in their relation to the occupational-environmental conditions under which they have been induced. Recognition of risk to a certain population and the identification of causativ

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Intrinsic Factors that can Affect Sensitivity to Chromosome Aberration Inductionnduction of chromosome aberrations by radiation and chemicals, is, at this time, difficult to answer. Furthermore, if such individuals can be identified there are social and legal implications concerning what action, if any, should be taken as far as their occupational or medical status is concerned

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Individual Variability in the Frequency of Sister Chromatid Exchange in Human Lymphocytesiques [2]. Although the mechanism(s) and the nature of the alterations leading to SCE are largely unknown, there are a number of observations suggesting a relationship between mutagenic and/or carcinogenic damage and an increased rate of SCEs [3]. Firstly there is a linear correlation between the in

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Detection of Mutated Erythrocytes in Manscence-activated cell sorter enumeration of cells carrying variant proteins. The first assay is based on the detection of erythrocytes containing the single amino acid-substituted hemoglobins S or C. Frequencies of anti-hemoglobin S- and C-labeled red cells in the blood of normal hemoglobin A indivi

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