Titlebook: In Vivo Neuromethods; Alan A. Boulton,Glen B. Baker,Alan N. Bateson Book 1998 Humana Press 1998

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In Vivo Methods for Studying Receptors, the consequences of transmitter release and receptor activation in vivo.However, over the last 15 yr there has been shift in focus toward studying receptors on CNS neurons maintained in vitro.The development of techniques for maintaming and recording from mammalian neurons in vitro has allowed for

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Animal Models of Anxiety and Depression,of these disorders, in order to facilitate their scientific study (Treit, 1994; Mineka, 1985; Marks, 1987; Willner, 1994). Within this broad context, animal models of anxiolytic or antidepressant drug action can be viewed as treatment models concerned with the pharmacological control of human anxiet

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Preclinical Behavioral Approaches to the Identification and Study of Antipsychotic Drug Action and ia is characterized by a spectrum of symptoms that are commonly grouped into positive (including hallucinations, incoherence, delusions, distorted thought, and incongruity of affect) and negative (including poverty of speech, flat affect, low social drive, curbing of interest, and diminished sense o

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Preclinical Behavioral Approaches for Assessing the Reinforcing Properties of Drugs of Abuse,he distribution, acquisition, and consumption of drugs of abuse continues to pose a major social, economic, and medical problem affecting increasing segments of our society. This observation has lead researchers to pose the question: what are the properties of abused substances that give rise to the

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In Vivo Animal Models of Teratogenicity,r with the placental barrier, acted as a shield and were a natural protection for the embryo from any maternal exposure to drugs. As subsequent findings of congenital malformations in humans exposed to various agents became apparent, e.g., Rubella (Gregg, 1941), nitrogen mustard (Haskin, 1948), andr

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The Relation of Brain Electrical Activity to Behavior,ed or immobilized by curare or by section of the brain stem (cerveau isolé) (Bremer, 1935) or spinal cord at level CI (encéphale isolé) (Bremer, 1936a, b). Such preparations are preferable to freely moving animals for many types of research since they simplify the technical problems of electrical re