Titlebook: Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors; John Vane,Jack Botting,Regina Botting Book 1996 Kluwer Academic Pub

支柱

墙壁

,Overview — mechanisms of action of anti-inflammatory drugs,, cell migration, tissue breakdown and repair. This overview will concentrate on the actions of anti-inflammatory drugs, with special reference to the prostaglandin system. This system is activated by phospholipase A., which liberates arachidonic acid, the substrate for cyclooxygenase (COX or PGH. s

AMEND

愉快么

The dilemma of two cyclooxygenases: identifying the roles of COX-1 and COX-2 in inflammation and apous interest shown in comparing COX-1 and COX-2 expression has led to the generalization that COX-1, which is found in most tissues of mammals, is involved in physiological regulation of homeostasis. COX-2, on the other hand, is involved in the inflammatory response and certain physiological phenome

并排上下

询问

垫子

漫步

COX-2 expression and inhibition in human monocytes,nd peroxidase activities.. PGH. is further metabolized by other enzymes to various prostanoids (PGs, prostacyclin and thromboxane A.). Two isozymes of PGHS exist, referred to as PGHS-1 and PGHS-2 or COX-1 and COX-2.. COX-1 is a constitutive enzyme present in almost all cell types., and is the major

NADIR

使声音降低