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Titlebook: Immunotoxins; Arthur E. Frankel Book 1988 Kluwer Academic Publishers 1988 Atmen.Staging.biology.cancer treatment.cell.hormones.leukemia.li

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楼主: 橱柜
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Immunotoxins containing single chain ribosome-inactivating proteinshydrates and promote the uptake of their A chain into cells [1–4]. Entry of the A chain of these toxins into the cytoplasm of a cell then results in the death of the cell by inactivation of its ribosomes. Members of this class of ribosome-inactivating proteins are extremely cytotoxic for cultured cell lines and are very poisonous for animals.
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Genetic engineering of immunotoxinsrphy discusses the use of genetic engineering to link genes together resulting in chimeric proteins. This review covers the first applications of genetic engineering technology to improve ITs by studying and altering toxin B chains and broadening the therapeutic index between target and nontarget cells.
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, exotoxin — Immunotoxinses of PE, how it has been used to make (ITs), and the cell-killing activity of PE ITs are discussed and the potency of ITs made using other toxins are compared. Finally, prospects for the future use of this toxin are discussed.
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978-1-4612-8419-2Kluwer Academic Publishers 1988
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Immunotoxins978-1-4613-1083-9Series ISSN 0927-3042 Series E-ISSN 2509-8497
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How protein toxins enter and kill cellsThe toxins described in this chapter (Table 1) are produced by certain pathogenic bacteria and certain poisonous plants. So far our knowledge is very limited as to the reason why these organisms produce toxins.
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Toxin selection and modification — OverviewA multitude of cell-type-specific toxins have been made by linking toxins to cell-surface binding moieties. This section focuses on the various toxins and toxin-related and toxin-derived proteins that have been used.
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