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Titlebook: Immunotoxicity Testing; Methods and Protocol Jamie C. DeWitt,Cheryl E. Rockwell,Christal C. Bow Book 2018Latest edition Springer Science+Bu

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发表于 2025-3-21 18:14:08 | 显示全部楼层 |阅读模式
书目名称Immunotoxicity Testing
副标题Methods and Protocol
编辑Jamie C. DeWitt,Cheryl E. Rockwell,Christal C. Bow
视频videohttp://file.papertrans.cn/463/462315/462315.mp4
概述Includes cutting-edge techniques for the study of immunotoxicity testing.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Immunotoxicity Testing; Methods and Protocol Jamie C. DeWitt,Cheryl E. Rockwell,Christal C. Bow Book 2018Latest edition Springer Science+Bu
描述This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed.  Written in the highly successful .Methods in Molecular Biology. format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, andtips on troubleshooting and avoiding known pitfalls. .Authoritative and practical, .Immunotoxicity Testing: Methods and Protocols, Second Edition. serves as a valuable contribution to the continued evolution and
出版日期Book 2018Latest edition
关键词Immunotoxicology; Immune function; Immunomodulatory agents; Pharmaceuticals; Health risk reduction; Xenob
版次2
doihttps://doi.org/10.1007/978-1-4939-8549-4
isbn_softcover978-1-4939-9322-2
isbn_ebook978-1-4939-8549-4Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2018
The information of publication is updating

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发表于 2025-3-21 23:34:10 | 显示全部楼层
Clinical Immunotoxicologyf useful endpoints. It is therefore common to use a weight of evidence approach with nonclinical studies to indicate if there is a cause for concern that the test article has immunotoxic potential. The most commonly used follow-up assay for immunosuppression is the T-dependent antibody response (TDA
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Investigative Immunotoxicologymical or biologic agents that alter the immune system and affect human health. Immunotoxicology can manifest in a variety of ways, with one of the most prominent effects being immunosuppression. Immunosuppression can be defined as a reduced ability of the immune system to respond to a challenge from
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The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)eep erythrocytes (sRBC). The assay enumerates the number of antigen-specific IgM antibody-producing cells in the spleen. When exposure to the test material takes place in vivo, as does sensitization, the actual quantification of the number of antibody-producing cells occurs ex vivo. Following the an
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Methylated Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice antigen. Interestingly both Th1, the classical, and Th17, the more recently discovered, proinflammatory lineages have been implicated in disease progression. The duality of DTH makes it an ideal model system for understanding T-cell differentiation, memory cell formation, and the direct effect of t
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Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessmentests to reduce the incidence of skin sensitization leading to clinical manifestations of ACD. For more than a decade, the murine local lymph node assay (LLNA) has been the method of choice for the identification of skin sensitizers. While the original LLNA protocol has been extensively evaluated and
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Enhanced Histopathology Evaluation of Lymphoid Organs the assumption that chemically induced alterations may result in qualitative or quantitative changes in the histology of the lymphoid organs. It involves the histological evaluation of various lymphoid organs and their respective tissue compartments to identify specific cellular and architectural c
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