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Titlebook: Immunotherapy of Renal Cell Carcinoma; Clinical and Experim Frans M. J. Debruyne (Director Chairman),Ronald M. Conference proceedings 1991

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Tumor Infiltrating Lymphocytes in Human Renal Cell Carcinoma: Adoptive Immunotherapy and Characterizs with reactivity to the autologous tumor [1–4]. Most of the infiltrating cells are X lymphocytes, with the number of CD8+ cells being greater than CD4+ cells [1–7]. Several human solid tumors have been reported to contain an increased frequency of cytotoxic precursors against autologous tumor when
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Interferon and Tumor Necrosis Factor in Renal Cell Carcinoma Model Systemsear after discovery. Advanced RCC is refractory to nearly all forms of systemic therapy. Hormonal therapy may result in a small proportion (0%–10%) of objective responses, but these are incomplete and of short duration. Single or combination chemotherapy also yields no clearly definable improvement in patient survival [19].
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Rationale for Immunotherapy in Renal Cell Carcinomaourse of their disease. Some 80% of the patients with disseminated disease will die within 3 years after surgery whereas 65% of patients with localized disease survive at least 5 years after diagnosis [7]
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Tumor Infiltrating Lymphocytes in Human Renal Cell Carcinoma: Adoptive Immunotherapy and Characterizcompared with peripheral blood lymphocytes [8]. In addition, recent studies have shown that TELs were therapeutically more potent than interleukin (IL)-2-activated spleen cells in several murine tumor models [9, 10].
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