Titlebook: Immunotherapy of Cancer; Methods and Protocol Patricia Yotnda Book 2010 Springer Science+Business Media, LLC 2010 Adoptive immunotherapy.An

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Characterization of Regulatory T Cells in Tumor Suppressive Microenvironments,s are discouraging so far. Recent studies showed that several subsets of regulatory tumor-infiltrating lymphocytes (TILs), such as naturally occurring CD4.CD25. regulatory T cells (Treg), and adaptively induced Treg cells of Tr1, Th3, CD8., as well as γδ Treg cells, have been identified in human can

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Generation of Cytotoxic T Lymphocytes for Immunotherapy of EBV-Associated Malignancies, success rates but can be associated with unwanted side-effects. Cytotoxic T cell (CTL)-based immunotherapy offers an alternative approach that is designed to specifically target protein antigens expressed in malignant cells and is thus likely to limit any adverse side-effects. Defining tumour-speci

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Enhanced Migration of Human Dendritic Cells Expressing Inducible CD40,to their use as a cellular vaccine in a number of clinical trials with promising results. However, the clinical efficacy of DC vaccines in patients has been unsatisfactory, probably because of a number of key deficiencies, including limited migration of ex vivo generated DCs to the secondary lymphoi

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Differentiation of Human Embryonic Stem Cells into Hematopoietic Cells In Vitro,d to treat diseases. In particular, successful generation of hematopoietic cells from ES cells could provide safer and less immunogenic cells than bone cells, obviating the need for severe host preconditioning when transplanted across major histocompatibility complex barriers. To generate hematopoie

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Gene Therapy to Improve Function of T Cells for Adoptive Immunotherapy, viral infections. However, the antitumor effect of adoptively transferred tumor-specific cytotoxic T lymphocytes (CTLs) is impaired by the limited capacity of these cells to expand within the tumor microenvironment. Administration of interleukin 2 (IL-2) has been used to overcome this limitation, b

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Cytokine-FC Fusion Genes as Molecular Adjuvants for DNA Vaccines,provides multiple potential class I and class II epitopes, thus bypassing limitations of MHC restriction; (2) bacterial plasmid DNA contains immunogenic unmethylated CpG motifs (immunostimulatory sequences) that may act as a potent immunological adjuvant; and (3) DNA is relatively simple to purify i

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Pharmacology of Anti-CD3 Diphtheria Immunotoxin in CD3 Positive T-Cell Lymphoma Trials,o single chain Fv fragments of an anti-CD3ɛ monoclonal antibody (UCHT1). A-dmDT.-bisFv(UCHT1) is capable of killing CD3. T-lymphoma cells and normal T cells specifically in the femtomolar concentration range. To study pharmacology of A-dmDT.-bisFv(UCHT1) in patients with CD3. T-cell lymphoma in a ph