Titlebook: Immunotherapy and Biomarkers in Neurodegenerative Disorders; Martin Ingelsson,Lars Lannfelt Book 2016 Springer Science+Business Media New

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Volumetric MRI as a Diagnostic Tool in Alzheimer’s Diseaseance imaging (MRI), have made it possible to study this pathological process in vivo. However, the use of clinical imaging in dementia evaluation is often suboptimal. Evidence supports the role of regional and global atrophy as well as white matter changes as markers of disease in dementia. There is

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PET Imaging as a Diagnostic Tool in Alzheimer’s Diseasetively intact. It is yet unclear which additional factors that ultimately will determine progression to mild cognitive impairment and eventually to AD dementia. Amyloid-β (Aβ) and tau imaging reveal in vivo the key protein aggregates seen in the AD brain and will help in early diagnosis. However, a

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Alpha-Synuclein as a Diagnostic Biomarker for Parkinson’s Diseasea. Although significant differences in the levels of total α-synuclein have been found between patients and controls, none of these markers have been proven clinically useful as there has been a substantial overlap between the groups. Instead, assessment of toxic prefibrillar α-synuclein species has

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Mass Spectrometry-Based Proteomics in Biomarker Discovery for Neurodegenerative Diseases), and amyotrophic lateral sclerosis (ALS) lead to disease-specific changes in the neuronal proteins. The usage of rapidly evolving proteomic technologies, such as mass spectrometry (MS), has opened new avenues to detect the changes in the protein expression in disease vs. control samples for unders

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Joakim Bergström,Martin Ingelsson M.D., Ph.D.ly all areas of clinical pathology, including disorders of the inner ear. As attention has focused increasingly on the role of viral infections in the pathogenesis of different diseases of the labyrinth, the body of clinical and experimental literature in this area has grown rapidly. In spite of the

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Johan Wikström M.D., Ph.D. 1,Torsten Danfors M.D., Ph.D.se have come about from the application of contemporary molecular biology, physiology, and imaging techniques that have been made available to all of biology in combination with discoveries in the domain of hearing. This volume, Clinical Aspects of Hearing, presents these pivotal developments as the

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