Titlebook: Immunotherapy; Aung Naing,Joud Hajjar Book Apr 20171st edition The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Overview of Basic Immunology for Clinical Investigators,cludes macrophages, dendritic cells, natural killer cells, neutrophils, mast cells, B cells, and T cells are found in the core, the invasive margin, or the adjacent stromal or lymphoid component of the tumor. The immune infiltrate is heterogeneous and varies within a patient and between patients of

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Harnessing the Immune System Against Leukemia: Monoclonal Antibodies and Checkpoint Strategies for gnostic factors, older age, or relapsed disease. The last decade has seen a surge in successful immune-based therapies in various solid tumors; however, the role of immune therapies in AML remains poorly defined. This chapter describes the rationale, clinical data, and toxicity profiles of immune-ba

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Immunotherapy in NSCLC: A Promising and Revolutionary Weapon,than 20% for all the newly diagnosed patients. Cisplatin-based cytotoxic chemotherapy for unresectable or metastatic NSCLC patients in the first line of treatment, and docetaxel in the second line, have achieved positive results but with limited benefit in overall survival. Targeted therapies for EG

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Cancer Imaging in Immunotherapy, those typically seen with conventional cytotoxic therapies. In fact, only 10% of patients on immunotherapy may show tumor shrinkage, typical of positive responses on conventional therapy. Conversely, those on immune therapies may initially demonstrate a delayed response, transient enlargement follo

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Overview of Basic Immunology for Clinical Investigators,lls and their role in tumor immune surveillance is of paramount importance to identify immune targets and to develop novel immune therapeutics in the war against cancer. In this chapter, we provide an overview of the individual components of the human immune system and the translational relevance of predictive biomarkers.