| 书目名称 | Immunosuppressant Analogs in Neuroprotection | | 编辑 | Cesario V. Borlongan,Ole Isacson,Paul R. Sanberg | | 视频video | | | 概述 | Includes supplementary material: | | 图书封面 |  | | 描述 | In recent years there has been a growing recognition that such widely used immunosuppressant drugs as cyclosporin and FK-506 and their analogs-the neuroimmunophilins-possess significant neurotrophic and neuroprotective properties in addition to their beneficial effects for transplant patients. In Immunosuppressant Analogs in Neuroprotection, pioneers in the field and leading neuroscientists and clinicians working with these drugs survey the most recent scientific evidence showing how they evolved from being purely immunosuppressant "drugs" to neuroprotective "agents." These authorities focus on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. They discuss their efficacy and mechanisms of action in vitro and in vivo; using these models of CNS disease, they report laboratory studies with compelling clinical indications for Alzheimer‘s disease, Huntington‘s disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction. They also present novel hypotheses on the me | | 出版日期 | Book 2003 | | 关键词 | Alzheimer; Nervous System; Parkinson; dopamine; forebrain; neurons; transplantation | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59259-315-6 | | isbn_softcover | 978-1-4684-9742-7 | | isbn_ebook | 978-1-59259-315-6 | | copyright | Springer Science+Business Media New York 2003 |
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发表于 2025-3-21 17:48:33
