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Titlebook: Immunoreceptor Tyrosine-based Inhibition Motifs; Marc Daëron,Eric Vivier Book 1999 The Editor(s) (if applicable) and The Author(s), under

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书目名称Immunoreceptor Tyrosine-based Inhibition Motifs
编辑Marc Daëron,Eric Vivier
视频video
概述Includes supplementary material:
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Immunoreceptor Tyrosine-based Inhibition Motifs;  Marc Daëron,Eric Vivier Book 1999 The Editor(s) (if applicable) and The Author(s), under
描述Novel molecular motifs named .Immunoreceptor Tyrosine-based . .Inhibition Motifs. (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.
出版日期Book 1999
关键词Activation; Antigen; Endoplasmatisches Reticulum; biology; cell; cytoplasm; immunoglobulin; immunoregulatio
版次1
doihttps://doi.org/10.1007/978-3-642-58537-1
isbn_softcover978-3-642-63634-9
isbn_ebook978-3-642-58537-1Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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978-3-642-63634-9The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/i/image/462281.jpg
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Interactions of LIRs, a Family of Immunoreceptors Expressed in Myeloid and Lymphoid Cells, with Viron usually occurs early in life with only mild and subclinical disease, followed by virus latency that can last for the lifetime of immunocompetent individuals. However, reactivation of the virus can occur in immuno-compromised patients, such as AIDS and transplant patients, and become a major cause of morbidity and mortality.
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LAIR-1, a Widely Distributed Human ITIM-Bearing Receptor on Hematopoietic Cells, the mechanisms underlying autoimmune disease. Here, a novel inhibitory receptor, LAIR-1, is discussed. LAIR-1 has a broad cellular distribution in the immune system and thus might play a role in the regulation of a variety of immune responses.
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