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Titlebook: Immunopathology in Toxicology and Drug Development; Volume 1, Immunobiol George A. Parker Book 2017 Springer International Publishing AG 20

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发表于 2025-3-21 18:16:10 | 显示全部楼层 |阅读模式
书目名称Immunopathology in Toxicology and Drug Development
副标题Volume 1, Immunobiol
编辑George A. Parker
视频video
概述Provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies..Offers an overview of general immunobiology, cells
丛书名称Molecular and Integrative Toxicology
图书封面Titlebook: Immunopathology in Toxicology and Drug Development; Volume 1, Immunobiol George A. Parker Book 2017 Springer International Publishing AG 20
描述.This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume., Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems., offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics...These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of .Immunopathology in Toxicology and Drug Development. are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
出版日期Book 2017
关键词drug development; histogenesis; immunomodulation; immunopathology; xenobiotic exposure
版次1
doihttps://doi.org/10.1007/978-3-319-47377-2
isbn_softcover978-3-319-83724-6
isbn_ebook978-3-319-47377-2Series ISSN 2168-4219 Series E-ISSN 2168-4235
issn_series 2168-4219
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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发表于 2025-3-21 23:50:43 | 显示全部楼层
Cells of the Immune System,t have secondary immunological functions. These subcategories are convenient for purposes of discussion, but extensive observations indicate there are many overlaps between cells of the various subcategories. Macrophages, in particular, occupy a functional space that is shared between the innate and
发表于 2025-3-22 02:49:31 | 显示全部楼层
Signaling and Effector Molecules in Immunity, molecules, all supported by a stromal framework that may provide additional immunomodulatory signals. Signaling and effector molecules of the immune system have been the focus of intense investigation in recent decades, resulting in a massive accumulation of relevant information. The aim of this ch
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Development of Immune System Organs,cology studies, in juvenile toxicology studies the pathologist and toxicologist must also be concerned with the influence of normal postnatal development on the histologic appearance and functional attributes of immune system tissues. In addition to direct age-related differences in histomorphology,
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Aging of Immune System Organs,due to structural alterations in immune system organs or depletion of immunocyte populations. However, other age-related alterations involve dysregulation and failures in coordination of various immunological functions. Aging effects on the innate immune system may result in a pro-inflammatory statu
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Flow Cytometry and Immunophenotyping in Drug Development,mune system alterations. Flow cytometry is an important tool that can be applied throughout drug development (e.g. early discovery to clinical monitoring) to evaluate immunobiological and immunotoxicological alterations resultant from therapies. Traditionally, flow cytometry has broad applications i
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Clinical Pathology Assays in Immunopathology, response to administration or withdrawal of a test item. A variety of assays can be performed in a clinical pathology laboratory with body fluids using either clinical pathology analyzers or other instruments. Information from the basic assays in clinical pathology, including hematology, clinical c
发表于 2025-3-23 05:52:20 | 显示全部楼层
Application of Immunohistochemistry in Toxicologic Pathology of the Hematolymphoid System,hat is routinely collected for toxicologic pathology assessment. This chapter will address which antigen markers are best used for assessing toxicologic effects in the hematolymphoid system and for diagnosing hematolymphoid neoplasms in FFPE tissues from mice and rats. These markers can be normally
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