Titlebook: Immunopathology in Toxicology and Drug Development; Volume 2, Organ Syst George A. Parker Book 2017 The Editor(s) (if applicable) and The A

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2168-4219 opment. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .978-3-319-83726-0978-3-319-47385-7Series ISSN 2168-4219 Series E-ISSN 2168-4235

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Immunopathology in Toxicology and Drug DevelopmentVolume 2, Organ Syst

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Spleen,tes in the white pulp are distributed into T cell-rich peri-arteriolar lymphoid sheaths and B cell-rich follicles, which work cooperatively to develop adaptive immune responses. A complex interplay between innate and adaptive immune cells and mediators makes the spleen important in the development o

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Immunopathology of the Male Reproductive Tract, also have dual immunologic and endocrinologic functions. The Sertoli cells and Leydig cells promote spermatogenesis on one hand, yet defend against immune activation and inflammation on the other. Understanding how the endocrine and immune systems interact will aid the pathologist in identifying or

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Immunopathology of the Musculoskeletal System,iated conditions affecting soft tissues (i.e., skeletal muscle and tendons) also are propelled by lymphocyte- and macrophage-derived pro-inflammatory cytokines. Immune system assaults on musculoskeletal tissues often are driven by a loss of self-tolerance to endogenous antigens (i.e., autoimmunity)

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Pde5-Inhibitors

response to rising populations and new technologies that allow land conversion to proceed at a faster pace. The argument is made that development per se is a major contributor to land degradation. Addressing land degradation, desertification and drought in the Mediterranean Basin includes policy ref