Titlebook: Immunology of Clinical and Experimental Diabetes; Sudhir Gupta Book 1984 Plenum Publishing Corporation 1984 Diabetes.Diabetes mellitus.Ins

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Antibodies to Insulin and Insulin Receptors: Mechanisms of Insulin Resistanceinsulin resistance is usually defined by the presence of hyperinsulinemia in the face of normal or elevated blood sugar or by resistance to exogenous insulin. Insulin resistance may occur in a large number of different disease states. The most frequent causes of mild to moderate insulin resistance a

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Genetic Basis of Type I (Insulin-Dependent) Diabetesetes. However, it must be acknowledged that at times it is not always possible to draw a clear clinical distinction between these two major forms of the disease. Generally, Type I diabetes presents mainly in childhood or adolescence and Type II diabetes mainly in middle or later life. This is by no

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Lymphocyte Response in Diabetes Mellitusbetes mellitus (Type I), which appears to be pathogenically a distinct disorder from insulin-independent diabetes (Type II). Studies in experimental animals have further suggested the role of lymphocytes and their subsets in the pathogenesis of Type I diabetes. It would be appropriate to discuss lym

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Autoimmunityar infiltration in and around the islets of Langerhans (Opie, 1901; Schmidt, 1902; Herbert, 1911). This lesion—later called . (von Meyenburg, 1940)—was thought to be rather specific for ketosis-prone diabetes mellitus, but was occasionally seen in endocrine disorders, such as idiopathic Addison’s di

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Antibodies to Insulin and Insulin Receptors: Mechanisms of Insulin Resistancehe syndrome of insulin resistance due to antireceptor antibodies and insulin resistance due to insulin antibodies. In both of these the patients are severely insulin-resistant and frequently fail to respond to 10 or even 1000 times or more the normal therapeutic dose of insulin.