Titlebook: Immunology and Alzheimer’s Diseasee; Colloque Medecine et Annick Pouplard-Barthelaix,Jean Emile,Yves Christe Conference proceedings 1988 Sp

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,The Blood-Brain Barrier in Cerebral Amyloidogenesis in Alzheimer’s Disease and Scrapie, review the evidence for blood-brain barrier dysfunction and for serum factors and blood-borne cells in cerebral amyloidogenesis in Alzheimer’s dementia and in scrapie. The hypothetical role of immunologically mediated injury to the central nervous system in both disorders is discussed. The basis of

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,Ultrastructural Study of Senile Plaques and Microvessels in the Brain in Alzheimer’s Disease,laques. All the senile plaques contained at least some amyloid fibrils, and these seemed to be produced at the basement membranes of capillary endothelial cells and projected into the surrounding parenchyma. Even when the senile plaques themselves appeared with light microscopy to lack amyloid fibri

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,Paired Helical Filaments in Alzheimer’s Disease: Their Formation and Transformation,ic anti-PHF immune serum..Tau proteins are the major antigenic components of PHF (as demonstrated by immunoblotting and immunocytochemistry using anti-PHF and anti-tau immune-sera). Moreover, we have studied the distribution of tau proteins in the different regions of a normal human brain. The anti-

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,The Molecular Basis of Cerebral Amyloidosis in Alzheimer’s Disease and the Unconventional Virus Discursor (PreA4), the gene for which is located on chromosome 21, in close proximity to the region involved in Down’s syndrome. The predicted structure of PreA4 suggests that it is an integral membrane glycoprotein. Knowledge of the mechanisms by which PreA4 is degraded to A4 may contribute to a bette

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,Genetics, Expression and Localization of the Amyloid Precursor of Alzheimer’s Disease, the form of plaques, vascular amyloid and neurofibrillary tangles. The A4 amyloid peptide is the morphopoetic principle of the amyloid fibrils and the cleavage product of a larger precursor protein. The gene for this A4 precursor encodes a primary translation product of 695 amino acids (Masters et

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