| 书目名称 | Immunological Synapse |
| 编辑 | Takashi Saito,Facundo D. Batista |
| 视频video | http://file.papertrans.cn/463/462194/462194.mp4 |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensit |
| 出版日期 | Book 20101st edition |
| 关键词 | Antigen; B-cell receptor; T-cell activation; antigen encounter; antigen recognition; cell-cell communicat |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-03858-7 |
| isbn_softcover | 978-3-642-26185-5 |
| isbn_ebook | 978-3-642-03858-7Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | Springer-Verlag Berlin Heidelberg 2010 |
|Archiver|手机版|小黑屋|
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