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Titlebook: Immunological Memory; David Gray,Jonathan Sprent (Member) Conference proceedings 1990 The Editor(s) (if applicable) and The Author(s), und

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发表于 2025-3-21 19:54:10 | 显示全部楼层 |阅读模式
书目名称Immunological Memory
编辑David Gray,Jonathan Sprent (Member)
视频video
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Immunological Memory;  David Gray,Jonathan Sprent (Member) Conference proceedings 1990 The Editor(s) (if applicable) and The Author(s), und
描述Although immunologists know rather a lot about the manif­ estation of immunological memory, an understanding of the mechanism of memory at cellular and biochemical levels eludes us. Indeed, as we shall see, it is not even clear which of the several models used to explain the working of memory approximates to the truth. It is in order to report on approaches to this problem and on recent experimental advances in the field of memory cells that this volume has been put together. In the past 4-5 years cell surface molecules that may enable us to define memory Band T cells have been identified. It may now be possible to ask how memory cells are generated and to define what signals are required during or after antigenic encounter for a cell to enter the memory cell pool rather than to terminally differentiate into an effector cell. The transition from virgin cell to memory cell is clearly accompanied by several biochemical changes. For B cells, isotype switching and somatic mutations (leading to affinity maturation) are well-defined phenomena, although the molecular mechanisms remain mys­ terious. Both have received attention in many excellent reviews of late and so are not considered in
出版日期Conference proceedings 1990
关键词Antigen; Immunologisches Gedächtnis; Memory-B-Zellen; Memory-T-Zellen; T-Zell-Merkmale
版次1
doihttps://doi.org/10.1007/978-3-642-75244-5
isbn_softcover978-3-642-75246-9
isbn_ebook978-3-642-75244-5Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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发表于 2025-3-21 20:13:43 | 显示全部楼层
Human T-Cell Memory,re of immunological memory still poses many problems. While it has often been assumed that memory cells are long-lived and not dependent on continuous or repeated antigenic stimulation, this view has been challenged by recent data which suggest that persistence of memory is dependent on continued antigen drive (G. and S. 1988).
发表于 2025-3-22 02:25:50 | 显示全部楼层
0070-217X ellular and biochemical levels eludes us. Indeed, as we shall see, it is not even clear which of the several models used to explain the working of memory approximates to the truth. It is in order to report on approaches to this problem and on recent experimental advances in the field of memory cells
发表于 2025-3-22 08:11:31 | 显示全部楼层
Expansion, Selection and Maintenance of Memory B-Cell Clones,itched to isotypes downstream of . and . (C. and C. 1977; B. et al. 1980), although many still express these isotypes (B. et al. 1980; Y. et al. 1985; Z.-B. et al. 1979) while carrying somatically mutated V genes (. et al. 1987; S. et al. 1987) and having different activation requirements (Y. et al. 1985, 1986; P. et al. 1984).
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Antiviral T-Cell Memory?,m disease by vaccination depends entirely on the existence of immunological memory. Although evidence for B-cell memory is abundant (K. 1977), it is not clear whether it is maintained by means of (a) persistence of antigen, (b) continuous exposure to cross-reactive “natural” environmental antigen, or (c) the existence of true memory B cells.
发表于 2025-3-22 19:07:43 | 显示全部楼层
Subsets of Rat CD4+ T Cells Defined by Their Differential Expression of Variants of the CD45 Antiged, but early work using alloantisera in mice established that T cells with different functional specializations could be distinguished phenotypically on the basis of whether or not they expressed what came to be called the CD8 antigen (C. and B. 1975).
发表于 2025-3-23 00:46:29 | 显示全部楼层
Suppressor T-Cell Memory,activity. Among the cybernetic mechanisms thought to be responsible for immuno regulation are antigen itself, antibody-mediated feedback, T-cell-dependent suppression and idiotypic networks (B. et al. 1980; N. 1983).
发表于 2025-3-23 02:02:14 | 显示全部楼层
ory decentralization (PD) that was introduced in Montevideo in the early 1990s by the Frente Amplio Leftist coalition. . The Frente Amplio municipal administration introduced a series of decentralization reforms that opened up participatory spaces and processes with the expressed goals of democratiz
发表于 2025-3-23 05:45:38 | 显示全部楼层
D. Gray,T. Leandersonory decentralization (PD) that was introduced in Montevideo in the early 1990s by the Frente Amplio Leftist coalition. . The Frente Amplio municipal administration introduced a series of decentralization reforms that opened up participatory spaces and processes with the expressed goals of democratiz
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