书目名称 | Immunological Memory |
编辑 | David Gray,Jonathan Sprent (Member) |
视频video | |
丛书名称 | Current Topics in Microbiology and Immunology |
图书封面 |  |
描述 | Although immunologists know rather a lot about the manif estation of immunological memory, an understanding of the mechanism of memory at cellular and biochemical levels eludes us. Indeed, as we shall see, it is not even clear which of the several models used to explain the working of memory approximates to the truth. It is in order to report on approaches to this problem and on recent experimental advances in the field of memory cells that this volume has been put together. In the past 4-5 years cell surface molecules that may enable us to define memory Band T cells have been identified. It may now be possible to ask how memory cells are generated and to define what signals are required during or after antigenic encounter for a cell to enter the memory cell pool rather than to terminally differentiate into an effector cell. The transition from virgin cell to memory cell is clearly accompanied by several biochemical changes. For B cells, isotype switching and somatic mutations (leading to affinity maturation) are well-defined phenomena, although the molecular mechanisms remain mys terious. Both have received attention in many excellent reviews of late and so are not considered in |
出版日期 | Conference proceedings 1990 |
关键词 | Antigen; Immunologisches Gedächtnis; Memory-B-Zellen; Memory-T-Zellen; T-Zell-Merkmale |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-642-75244-5 |
isbn_softcover | 978-3-642-75246-9 |
isbn_ebook | 978-3-642-75244-5Series ISSN 0070-217X Series E-ISSN 2196-9965 |
issn_series | 0070-217X |
copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |