Titlebook: Immunoinformatics; Namrata Tomar Book 2020Latest edition Springer Science+Business Media, LLC, part of Springer Nature 2020 Epitope predic

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A New Approach to Assess mAb Aggregation, mAb as bait for screening of a phage display peptide library and identifying those peptides with random sequence which can recognize mAb aggregates. The selected peptides can be used for developing homogeneous quantitative methods to assess mAb aggregation. Results indicate that a peptide-binding m

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Generation of Variability-Free Reference Proteomes from Pathogenic Organisms for Epitope-Vaccine Deses. Vaccine design strategies should be aimed to counteract such variability, targeting the conserved antigen regions of the pathogen. Sequence variability analysis allows the identification of conserved regions upon multiple sequence alignments of the relevant antigens. In this chapter, we describ

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Immunoinformatic Approaches for Vaccine Designing Against Viral Infections,laborious process requiring time and economy. Many approaches have been made to reduce the times and economy of vaccine development. In this regard, immunoinformatic approach is supposed to bring a revolution in vaccine development. This chapter provides an overview of immunoinformatics and its appl

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SVMTriP: A Method to Predict B-Cell Linear Antigenic Epitopes,acilitate this process and improve its efficiency, computational methods were developed to predict antigenic epitopes. For the linear B-cell epitope prediction, many methods were developed, including BepiPred, ABCPred, AAP, BCPred, BayesB, BEOracle/BROracle, BEST, and SVMTriP. Among these methods, S

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,Modeling Phage–Bacteria Dynamics, into the dynamics of phage and bacteria. Besides its intrinsic value, a somewhat underutilized aspect of such insight is that it can provide beneficial inputs toward better experimental design. In this chapter, we discuss several modeling techniques that can be used to study the dynamics between ph

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,Dynamics of Mycobacteriophage—Mycobacterial Host Interaction,re employed earlier to evade the pathogenesis but AMR became threatened. Molecular tools employing bacteriophage can be an alternative to effective treatment against Mycobacterium. Phage treatment using phage-encoded products, such as lysins, causes lysis of cells; particularly bacteria could be use

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Reverse Vaccinology and Its Applications,rk on a totally different paradigm. Hence this method helps in the discovery of novel mechanisms of immune intervention. Epitope-based immune-derived vaccines (IDV) are generally considered to be safe when compared to other vectored or attenuated live vaccines. Epitope-based IDV may also provide ess