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Titlebook: Immunobiology of Proteins and Peptides IV; T-Cell Recognition a M. Zouhair Atassi Book 1987 The Editor(s) (if applicable) and The Author(s)

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发表于 2025-3-21 19:51:48 | 显示全部楼层 |阅读模式
书目名称Immunobiology of Proteins and Peptides IV
副标题T-Cell Recognition a
编辑M. Zouhair Atassi
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Immunobiology of Proteins and Peptides IV; T-Cell Recognition a M. Zouhair Atassi Book 1987 The Editor(s) (if applicable) and The Author(s)
描述This symposium was established in 1976 for the purpose of bringing to­ gether once every two or three years, active investigators in the fore­ front of contemporary immunology, to present their findings and to discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the under­ standing of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptides which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has finally occurred and many applications of these peptides are now being realized. The main symposia topics of the fourth symposium were: T-cell recognition of proteins, structure and function of the T-cell receptor, presentation of protein antigens, recycling and activation of membrane receptor molecules, Ir-gene control of T-cell responses and methods of cell separation. The molecular features recognized by antibodies on proteins were the first immune recognition sites to be local ized and
出版日期Book 1987
关键词antibody; antigen; immunobiology; immunology; proteins
版次1
doihttps://doi.org/10.1007/978-1-4684-5442-0
isbn_softcover978-1-4684-5444-4
isbn_ebook978-1-4684-5442-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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Murine Ia Genes: Organization, Polymorphism and Heterogeneity,s evolved millions of years ago, and that they are part of a super-gene family. Studies in man and mouse have clearly identified at least four classes of MHC genes, class I, class II, class III and class IV. The class I genes code for the classical ‘transplantation antigens’ which consist of a 45,00
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Trinitrophenyl Reactive T-Cell Clones in Functional and Molecular Analysis of the HLA-D Region,ong the seminal studies demonstrating this phenomenon . those of Shearer and associates demonstrating that recognition of mouse target cells by trinitrophenyl (TNP)-specific cytolytic T cells required genetic homologies between the killer and target cells at H-2 class I loci (rev., Shearer et al., 1
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T-Cells Recognize IA Conformation in the Interaction with Antigen Presenting Cells,minant (Shevach and Rosenthal, 1973). Although the T cell antigen receptor has been identified and sequenced (Hedrick et al., 1984; Fink et al., 1986), the nature of the ligand that triggers the T cells remains unclear. The early experiments of Lin et al. (1981) and Michaelides et al. (1983) using t
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T-Cell Recognition and Antigen Presentaion of Myoglobin,ncide with the antigenic sites while one site was recognized exclusively by T cells and not by any detectable levels of antibody. Recognition of the synthetic T sites by protein-primed T cell lines or clones indicated that T cells display an unusual peptide size requirement beyond the essential cont
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T-Cell Recognition and Antigen Presentation of Lysozyme,re involved in B- and T-cell recognition. The strategy depends on the synthesis of consecutive overlapping peptides that together account for the entire protein chain. Using this approach, the full submolecular profile of continuous regions on hen egg lysozyme recognized by T cells (T sites) were lo
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,The Regions of T-cell Recognition on the Extracellular Part of the α Chain of ,, Acetylcholine ReceChR). Eighteen synthetic consecutive overlapping peptides, of uniform size and overlaps, that spanned the entire extracellular part (residues 1–210) of the a chain were examined for their . stimulation of lymph node cells from AChR-primed C57BL/6 (H-2.), C3H/He (H-2.), SWR(H-2.) and SJL (H-2.) mice.
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Structural Considerations of T-Cell Cognizance of Antigen,R are I-A. and I-A. respectively. Using various antigens to stimulate, ., primed T lymphocytes, studies on the responsiveness of these two strains to immunization with TMVP and with its tryptic peptide number 8 representing residues 93–112 of the protein are described. These studies revealed that in
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