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Titlebook: Immunity, Tumors and Aging: The Role of HSP70; Igor Malyshev Book 2013 The Author(s) 2013 Age-related Diseases.Cardiovascular.Heat Shock P

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发表于 2025-3-21 19:47:15 | 显示全部楼层 |阅读模式
书目名称Immunity, Tumors and Aging: The Role of HSP70
编辑Igor Malyshev
视频video
概述Includes supplementary material:
丛书名称SpringerBriefs in Biochemistry and Molecular Biology
图书封面Titlebook: Immunity, Tumors and Aging: The Role of HSP70;  Igor Malyshev Book 2013 The Author(s) 2013 Age-related Diseases.Cardiovascular.Heat Shock P
描述The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer‘s disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.
出版日期Book 2013
关键词Age-related Diseases; Cardiovascular; Heat Shock Proteins; Immunology; Tumors
版次1
doihttps://doi.org/10.1007/978-94-007-5943-5
isbn_softcover978-94-007-5942-8
isbn_ebook978-94-007-5943-5Series ISSN 2211-9353 Series E-ISSN 2211-9361
issn_series 2211-9353
copyrightThe Author(s) 2013
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A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle, HSP70 forms a unified ATPase cycle coupled with connection and disconnection of the client protein. The “team” of HSP70 cycle regulators includes., which delivers clients to HSP70 and stimulates ATP hydrolysis;., which assists HSP70 in retaining the client, and. and., which accelerate the dissociation of ADP and the release of the client protein.
发表于 2025-3-22 08:01:28 | 显示全部楼层
The Functions of HSP70 in Normal Cells,f the protein, sends the protein either for re-folding or for degradation. Because of the FORD machinery, a cell maintains protein homeostasis. The HSP70 ATPase cycle also controls the activity of key signalling proteins by maintaining these proteins in an inactive or active state by regulating their levels and by intracellular transport.
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HSP70 in the Immune Responses,erefore stimulate an adaptive response. The third factor is the circumstances of synthesis and release of HSP70 from the cell. For example, in the case of microbial invasion, HSP70 s are involved in the formation of antigen-dependent immune memory, and in the case of different stresses in the formation of antigen-independent immune memory.
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uncivil elements, dropping the idea of a societal sphere and focusing exclusively on civility (Dieter Rucht), reconceptualizing civil society as a civil(izing) sphere (Jeffrey Alexander), or focusing more on elements that can foster civility in voluntary associations.
发表于 2025-3-23 08:47:12 | 显示全部楼层
Igor Malyshev uncivil elements, dropping the idea of a societal sphere and focusing exclusively on civility (Dieter Rucht), reconceptualizing civil society as a civil(izing) sphere (Jeffrey Alexander), or focusing more on elements that can foster civility in voluntary associations.
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