书目名称 | Immune Metabolism in Health and Tumor | 编辑 | Bin Li,Fan Pan | 视频video | | 概述 | First book focusing on immune cell metabolism.Discussing the critical role of immune cell metabolism in regulating normal cell physiology, as well as immune cell functions in tumors.Providing a cuttin | 丛书名称 | Advances in Experimental Medicine and Biology | 图书封面 |  | 描述 | .This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients...The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively | 出版日期 | Book 2017 | 关键词 | Cell Differentiation and Function; Immunity; Metabolism; Posttranslational Modification; Tumor Microenvi | 版次 | 1 | doi | https://doi.org/10.1007/978-94-024-1170-6 | isbn_softcover | 978-94-024-1502-5 | isbn_ebook | 978-94-024-1170-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 | issn_series | 0065-2598 | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 201 |
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