书目名称 | Immune Infertility | 副标题 | The Impact of Immune | 编辑 | Walter K.H. Krause,Rajesh K. Naz | 视频video | | 概述 | Written by experienced and acknowledged experts.First comprehensive overview of immune reactions inducing fertility disorders in both sexes.Reader-friendly structure.Includes supplementary material: | 图书封面 |  | 描述 | Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2–30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was no | 出版日期 | Book 20091st edition | 关键词 | Antigen; assisted reproduction; clinical trial; contraception; fertility; immune chemistry; immune contrac | 版次 | 1 | doi | https://doi.org/10.1007/978-3-642-01379-9 | isbn_softcover | 978-3-642-42286-7 | isbn_ebook | 978-3-642-01379-9 | copyright | Springer-Verlag Berlin Heidelberg 2009 |
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