Titlebook: Imaging, Cerebral Topography and Alzheimer’s Disease; Stanley I. Rapoport,Henri Petit,Yves Christen Conference proceedings 1990 Springer-V

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Research and Perspectives in Alzheimer‘s Diseasehttp://image.papertrans.cn/i/image/461821.jpg

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Summary Comments on Presentations,onnected with association neocortical areas) are more vulnerable to Alzheimer’s disease than are other brain regions. This principle of selective regional vulnerability also applies, with different areas being affected, to Huntington’s disease, Parkinson’s disease, Pick’s disease, and several other neurodegenerative disorders.

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,Cellular Pathology in Alzheimer’s Disease: Implications for Corticocortical Disconnection and Diffecorticocortical and hippocampal circuits are compromised. In fact it has been suggested that a global corticocortical disconnection occurs in Alzheimer’s disease, thereby disrupting cohesive, integrated cortical functions and leading to dementia. Our efforts in Alzheimer’s disease research are proce

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,Distribution of Neurochemical Deficits in Alzheimer’s Disease,ed in Alzheimer’s disease. It is, however, highly likely that shrinkage or loss of corticocortical pyramidal neurones is a key change. This change appears to be circumscribed and clinically relevant and to involve neurotransmitter glutamate. The putative pathogenic role of glutamate is briefly discu

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