Titlebook: Imaging of Hypoxia; Tracer Developments Hans-Jürgen Machulla Book 1999 Springer Science+Business Media Dordrecht 1999 SPECT.Tumor.cardiolog

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Molecular Design Approaches of Hypoxia Tracers,. One of those observations detected the inversely correlated toxicity of organic compounds to their water solubility. Studies like that led to the later formulation of Quantitative Structure Activity Relationships (QSAR).

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Mammal

Quantifying Hypoxia with Radiolabeled Fluoromisonidazole: Pre-Clinical and Clinical Studies,cal or physiological properties of tumors influence outcome of therapy? What drug or molecule is a natural substrate, precursor, or marker for the property of interest? Which characteristics of tumors are quantitatively, if not qualitatively different from normal tissues? Tumor hypoxia emerged as a

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NADIR

The Evaluation of Hypoxia in Diabetes,mains very good. However, even in the presence of good disease control, long term diabetes patients are prone to a variety of complications that contribute to morbidity and mortality. The majority of these complications have their basis in macrovascular and microvascular changes that appear to arise

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Brocas-Area

h a large variety of theoretical and experimental datagive clearly proven indications. During incidences and progress ofmany types of diseases hypoxia may enhance development and progress ofthe disease and, furthermore, decrease chances of efficient treatmentof, e.g., tumors. Hypoxic tumor cells are

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Book 1999variety of theoretical and experimental datagive clearly proven indications. During incidences and progress ofmany types of diseases hypoxia may enhance development and progress ofthe disease and, furthermore, decrease chances of efficient treatmentof, e.g., tumors. Hypoxic tumor cells are up to thr

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The Evaluation of Hypoxia in Diabetes,rovascular pathology is evident. This microangiopathy has a multifunctional pathogenesis although it is believed that a primary mechanism is at work from the beginning of diabetes which contributes to progressive vascular disease.

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Detection of Liver Hypoxia by [18F]Fluoromisonidazole and Application in Liver Transplant Disordersreas under hypoxic perfusion conditions, the β-glucuronide is a minor metabolite (Smith 1983). Due to this hepatic metabolism including biliary excretion, it has been questioned whether FMISO would be a suitable tracer for liver hypoxia imaging. Detection and quantification of liver hypoxia, however, would highly improve our knowledge