Titlebook: Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing; A Big Chapter in the Khalid El Bairi Book 2020 The Editor(s) (if app

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An Introduction to the Current Management of Colorectal Cancer in the Era of Personalized Oncology,edictive biomarkers have been recently added to conventional schemes to select patients who may be more likely to benefit from treatments. In colorectal cancer, fluoropyrimidine-based chemotherapy is still the backbone of systemic treatment. Other drugs such as irinotecan and oxaliplatin as well as

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Next-Generation Sequencing for Colorectal Cancer Management,nosis and prediction of prognosis and response to treatments. Next-generation sequencing (NGS) tests enable refinement of the selection of CRC patients to benefit from recent targeted therapies. These advances constitute a rationale for the emerging targeted therapies that are changing the patients’

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Gut Microbiota, Next-Generation Sequencing, Immune-Checkpoint Inhibitors, and Colorectal Cancer: Houdy of gut microbiota and its association with disease. Intestinal microbiota influences host immunity and may profoundly interact with mucosal environment and induce its perturbation by various mechanisms involving genetic and metabolic by-products. Current evidence suggests a primary and fundament

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The Revolution of Liquid Biopsy and Single-Cell Sequencing in the Management of Colorectal Cancer,tools have focused on pretreatment factors. However, there is an enthusiastic interest in liquid biopsy in cancer mainly with the potential findings from human studies impacting clinical practice. In CRC as well as other malignancies, liquid biopsy has the potential to detect, characterize, and moni

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Overview of Cost-Effectiveness and Limitations of Next-Generation Sequencing in Colorectal Cancer,icantly impacted the management of cancer. Progressing from the detection of gene alterations and data analysis to actionability, targeted and whole-genome NGS has resulted in a better understanding of cancer genetics and its potential impact on patients’ outcomes. In alignment with the broader land

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