Titlebook: IgG4-Related Kidney Disease; Takao Saito,John H. Stone,Mitsuhiro Kawano Book 2016 Springer Japan 2016 IgG4.IgG4-related disease.IgG4RKD.Me

Eosinophils

Characteristic Distribution of Inflammatory Lesions in IgG4-Related Kidney Disease: Findings from Authe same kidneys. Storiform fibrosis (bird’s-eye pattern fibrosis) was limited to the cortex. These results indicate that inflammation or fibrosis is predominantly located in the renal cortex and perivasculature in IgG4-related TIN. Of note is that the lesions showed a predilection to develop around

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IgG4-Related Disease: History and Overviewtrations of IgG4+ plasma cells within affected tissues. IgG4-RD is currently considered to be an immune-mediated condition with possible contributions from autoimmunity, but the precise mechanisms remain to be established. The characteristic features of IgG4-RD can be summarized as follows: (1) syst

Encephalitis

IgG4-Related Disease: Pathological Features and Differential Diagnosist be diagnosed based on morphological features and immunohistochemical findings. The changes that occur are basically similar in any organ manifestation, with several site-specific findings being recognized. This newly formed systemic condition has a broad range of differential diagnoses, including

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Potential Pathways in the Pathogenesis of IgG4-Related Disease affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received i

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IgG4-Related Kidney Disease: Clinical and Laboratory Featuresand both the overall disease and its renal manifestations are more likely to affect more males than females. Most patients with IgG4-RKD also express features of the disease in other organs, often manifesting a broad range of the varied inflammatory and allergic conditions associated with the underl

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