Titlebook: ISAC and ARIEL: The TRIUMF Radioactive Beam Facilities and the Scientific Program; A Laboratory Portrai Jens Dilling,Reiner Krücken,Lia Mer

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M. Dombsky,P. Kunzfrom the presence on the capillary surface of weakly acid hydroxyl groups attached to the silicon atoms. Different authors have reported an overall pKa value of 5.3 (.) or 6.3 (.) for surface silanols. In practice, when the capillary surface is bathed in any buffer solution with a pK higher than 2,

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Pierre G. Bricault,Friedhelm Ames,Marik Dombsky,Peter Kunz,Jens Lassencedures that permit use of this new resource for the analysis of genetic variation and for the detection of disease-causing mutations. The advent of capillary electrophoresis (CE), with its power to separate and a- lyze very small amounts of DNA, has also stimulated researchers to develop analytical

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F. Ames,R. Baartman,P. Bricault,K. Jayamannahod for the screening of unknown mutation in small stretches of DNA. Its widespread use is related to its simplicity and low cost. SSCP analysis is based on the principle that ssDNA with a single base substitution (or containing a small sequence deletion or insertion) often assumes an altered folded

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Richard Baartmanly slow and labor intensive. Capillary gel electrophoresis is now becoming recognized as an important alternative to slabs since it offers higher throughput and automation (.). Nevertheless, the fast growing need for DNA analysis capacity due, for example, to the sequencing of entire genomes and the

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M. Marchetto,R. E. Laxdalch as isoelectric point or molecular weight, or in terms of purity/heterogeneity for the presence of charge or size variants. In glycoproteins the heterogeneity occurring as a consequence of variable amounts of terminal sialic acid residues on glycan moieties can be detected by CE. As such, a capill

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A. B. Garnsworthy,P. E. Garrettyte binding. FACCE involves continuous sampling, integrating sample injection and separation into one process that provides advantages over conventional frontal chromatography. The method provides rapid and precise determination of binding isotherms, and allows for quantitative binding analysis in t