Titlebook: INCREaSE 2019; Proceedings of the 2 Jânio Monteiro,António João Silva,Nelson Sousa Conference proceedings 2020 Springer Nature Switzerland

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Célia Quintas,Paula Pires-Cabralird, we highlight an inherent crosslink between the stochastic and deterministic frameworks and discuss its implications. For increased accessibility the chapter is split into an informal presentation of the results using a minimum of mathematical formalism and a rigorous mathematical treatment for

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Christine Iglesias,Cátia Morgado,Manuela Guerra,António Fernandes,Carlos Brandão However, few computational pipelines are available to the public to perform systematic DNA methylation analysis. Utilizing open source tools, we here describe a comprehensive computational methodology to thoroughly analyze DNA methylation patterns during tumor evolution based on bisulfite converted

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Oana-Viorela Nistor,Cristina-Diana Zaharia,Doina Georgeta Andronoiu,Gabriel Danut Mocanu,Viorica Vasrom MS-based phosphoproteomics data. We start with a short explanation of the fundamental features of the phosphoproteomics data acquisition process from the perspective of the computational analysis. Next, we briefly review the existing databases with experimentally verified kinase-substrate relati

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Cátia Morgado,Patrícia Bernardo,Inês Henriques,Susana Jesus,Andreia Rego,Inês Delgado,Inês Coelho,Isdressed via multiscale modelling. Enhanced understanding of the initial hallmarks of cancer, extended to the control of metabolism and stress, is opening novel avenues for cancer diagnosis and treatment. It is fully expected that further progress will take place through iterative cycles of experimen

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Liliana Ceclu,Oana-Viorela Nistor,Doina Georgeta Andronoiu,Gabriel Danut Mocanu,Viorica Vasilica Barlity in circadian entrainment, cell cycle length, and phase durations, which determine the success of cancer chronotherapeutics. Stochastic and deterministic models further confirm the poor therapeutic value of constant-rate infusion or wrongly-timed chronomodulated infusion. The integration of the

Immunization

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Nitrate Reductase Activity in Green Macroalgae as an Environmental Indicator of Temperature and Sali and . have maximum NRA at salinities of 36 g/kg, although nitrate reduction can occur in freshwater or brackish water, but at significantly lower rates. NRA varied significantly with temperature for both macroalgae, although . showed maximum NRA at 30 °C, while NRA peaked at 35 °C in .. Likely adeq

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Spatial and Meteorological Behaviour of Daily Ozone Air Pollution in the Bay of Algeciras (2010–2015 objectives has been to develop an estimation approach for any hypothetical damaged station using the other monitoring stations and the meteorological variables. Consequently, we have studied the leverage between all the variables and Ozone pollutant using Principal Component Analysis (PCA), togethe

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