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Titlebook: IMMS’ General Textbook of Entomology; Volume I: Structure, O. W. Richards,R. G. Davies Book 1977 O. W. Richards and R. G. Davies 1977 Embry

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O. W. Richards M.A., D.Sc., F.R.S.,R. G. Davies M.Sc.ce antigen expression, from an established culture of Gleason 4 (2+2) prostate cancer (P4E6), were able to form multiple intraprostatic tumours in nude mice when grafted orthotopically in a matrigel plug containing human prostatic stroma. The final tumours re-expressed androgen receptor and displaye
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O. W. Richards M.A., D.Sc., F.R.S.,R. G. Davies M.Sc.tant, . delivery of BMP4 effectively blocks the tumour growth and associated mortality which occur in 100% of control mice in less than 12 weeks, following intracerebral grafting of human GBM cells. These findings show that the BMP-BMPR signalling system, which controls the activity of normal brain
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O. W. Richards M.A., D.Sc., F.R.S.,R. G. Davies M.Sc. Analysis methods are described for the quantification of CSC spheroid proliferation and viability tracking, throughout culture by on-plate alamarBlue fluorescence. Additional viability assays are described utilizing confocal microscopy with Live/Dead Viability/Cytotoxicity Kit. The characterization
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O. W. Richards M.A., D.Sc., F.R.S.,R. G. Davies M.Sc.CD44, particularly CD44v isoforms, are cancer stem cell (CSC) markers and critical regulators of cancer stemness, including self-renewal, tumor initiation, and metastasis. Thus, CD44 is widely used alone or in combination with other cell surface markers to isolate or enrich CSCs through fluorescence
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O. W. Richards M.A., D.Sc., F.R.S.,R. G. Davies M.Sc.ated with chemotherapy, most of the dividing cells are killed, but this leaves a small subset of cells that have the ability to remake the entire tumor. These are cancer stem cells. They possess the signals of self-renewal and yet can also differentiate. If one could understand more about the cells
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