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Titlebook: Hypoxia, Metabolic Acidosis, and the Circulation; Allen I. Arieff Book 1992 American Physiological Society 1992 Hypoxia.Metabolic Acidosis

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Alkalinizing Agents for the Treatment of Cardiac Arrest mEq (3.75 g) at intervals of 5–10 min during cardiac resuscitation. The use of sodium bicarbonate was further supported by clinical reports documenting severe metabolic acidosis during CPR in patients whose cardiac function was restored when sodium bicarbonate was administered (28,45,97,98).
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d finally, at the level of the entire organ.Gives an overvieIn recent years, there has been a wealth of new information on the physiological and biochemical consequences of hypoxia, or low blood levels of oxygen. This new volume discusses the implications of these new findings on the pathophysiology
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https://doi.org/10.1007/978-3-663-15750-2ly, that acidosis causes pulmonary vasoconstriction, that CO. may exert both vasodilator and vasoconstrictor influences and, most recently, that acidosis enhances hypoxic pulmonary vasoconstriction (HPV).
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Effects of Sodium Bicarbonate on Myocardial Metabolism and Circulatory Function during Hypoxiaof sodium bicarbonate in these circumstances have failed to demonstrate any impact of sodium bicarbonate therapy on outcome, and some studies have suggested potentially adverse effects of this therapy. In this chapter a critical appraisal of the effects of sodium bicarbonate therapy on the heart, lungs, and circulation is presented.
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