Titlebook: Hypoxia in Cancer: Significance and Impact on Cancer Therapy; Sukhes Mukherjee,Jagat Rakesh Kanwar Book 2023 The Editor(s) (if applicable)

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Role of Hypoxia and Reactive Oxygen Species in Cancer Biology,h also is associated with oxygen. This chapter will discuss the crucial role of hypoxia and ROS in cancer initiation and progression. Besides, this chapter also will provide a comprehensive overview, focusing on the contribution of hypoxia and ROS in cancer biology. This chapter also summarizes the updated information on hypoxia and ROS.

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Hypoxia and Its Biological Implications for Cancer Therapy,mon characteristic feature of solid tumors, is caused by structural and functional modifications in microvasculature. Hypoxia-inducible factor-1 (HIF-1) is the principal regulator of physiological adaptations to hypoxia that activates the expression of battery of target genes, leading to the develop

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Role of Hypoxia and Reactive Oxygen Species in Cancer Biology,es like cancer. The critical roles of hypoxia and reactive oxygen species (ROS) on human health have been investigated comprehensively over the years. Numerous scientific evidence from various laboratory and clinical investigations points toward the role of hypoxia in cancer. Besides, ROS also plays

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Hypoxic Tumor Microenvironment: Driver for Cancer Progression,ical steps of tumor progression ranging from angiogenesis, lymphangiogenesis to metastasis and resistance to cancer therapies. It is regulated by a family of transcription factor HIF-1α, which is a master regulator controlling a wide variety of genes involved in cancer progression. In recent years,

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Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression,s induced via replicative exhaustion due to telomere shortening, in preneoplastic cells it emerges as a cellular failsafe program provoked by oncogenic activation and serves as an initial barrier constraining the malignant progression. Regulation of senescence is influenced by various intrinsic and

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Hypoxia-Regulated Gene Expression and Metastasis,he condition of insufficient oxygen supply at the tissue level. Commonly hypoxia is known as a characteristic feature of solid tumors playing an important role in supporting tumor progression and metastasis by promoting various processes such as angiogenesis or epithelial to mesenchymal transition (