书目名称 | Hypocretins | 副标题 | Integrators of Physi | 编辑 | Luis Lecea,J. Gregor Sutcliffe | 视频video | | 概述 | Represents an interdisciplinary approach to hypocretins that reviews the role of these neuropeptides in neurological disease.Includes supplementary material: | 图书封面 |  | 描述 | The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We w | 出版日期 | Book 2005 | 关键词 | Hypocretins; Integrators; Physiological; anatomy; brain; hormone; metabolism; neurons | 版次 | 1 | doi | https://doi.org/10.1007/b107412 | isbn_softcover | 978-1-4614-9806-3 | isbn_ebook | 978-0-387-25446-3 | copyright | Springer-Verlag US 2005 |
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