Titlebook: Hyperthermic Oncology from Bench to Bedside; Satoshi Kokura,Toshikazu Yoshikawa,Takeo Ohnishi Book 2016 Springer Science+Business Media Si

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Thermo-Tolerancece. Thermo-tolerance restricts the effectiveness of hyperthermia and combined therapy of hyperthermia and radio-therapy. Heat shock proteins (HSPs) are reported to play important roles in thermo-tolerance of cells. However, the details of the molecular mechanism in which HSPs restore or repair prote

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Inhibition of DNA Repair System Activityse it causes protein denaturation, which strongly depresses DNA repair mechanisms that otherwise contribute to the development of radio- and chemo-resistance. Therefore, hyperthermic therapy has been utilized to augment traditional cancer treatments such as radiotherapy and chemotherapy. Recently re

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