Titlebook: Hybridoma Technology in the Biosciences and Medicine; Timothy A. Springer Book 1985 Springer Science+Business Media New York 1985 antibody

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Overview: 978-1-4684-4966-2978-1-4684-4964-8

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https://doi.org/10.1007/978-1-4684-4964-8antibody; antigen; antigen presentation; genetics; immunoglobulin; immunotherapy; interferon; lymphocytes; p

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Strategies for Production of Human Monoclonal Antibodiese hybridoma MAbs has been refined enormously since it was introduced in 1975,. the technology for generating human MAbs initially lagged behind. However, recent advances now make it reasonable to suggest that it will soon be possible to generate human antibodies with as much success as murine antibo

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The Antibody Combining Sitecture (the complementarity-determining regions), are arranged to form the surface that binds antigen. The amino acid sequences of the polypeptide chain segments that fold to form this region (approximately 60 amino acid residues) determine the nature of the antigen recognized. Three segments of the

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The Generation of Better Monoclonal Antibodies through Somatic Mutation the many benefits of hybridoma technology are the potential of obtaining pure antibodies from impure immunogens, the chemical homogeneity of monoclonal antibodies, making them reliable reagents, the large amounts of antibody that can be generated, and the ability to renew exactly the same antibody

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Switching the Isotype of Monoclonal Antibodieshe specificity of the humoral immune response to generate virtually unlimited amounts of monoclonal antibody of desired specificity. Unfortunately, a selected hybridoma may fail to secrete specific immunoglobulin with an isotype of desired functional activity. This problem may be alleviated through

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The Analysis of Structural Diversity in the Antibody Responserge amounts of a single immunoglobulin molecule, which could not be obtained from normal immune sera. The discovery that multiple myelomas were tumors originating from a single clone of antibody-producing cells and hence gave rise to a homogeneous source of immunoglobulin was therefore extremely imp