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Titlebook: Hybrid Systems Biology; 5th International Wo Eugenio Cinquemani,Alexandre Donzé Conference proceedings 2016 Springer International Publishi

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Relationship Between the Reprogramming Determinants of Boolean Networks and Their Interaction Graphhronous dynamics. Given two fixed points of a Boolean network, we are interested in all the combinations of mutations which allow to switch from one fixed point to the other, either possibly, or inevitably. In the case of existential reachability, we prove that the set of nodes to (permanently) flip
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Discrete Abstraction of Multiaffine Systemsproperties of interest directly. A common strategy to tackle this problem is to construct and analyze a discrete overapproximation of the original system. However, the conservativeness of a discrete abstraction significantly determines the level of confidence we can have in the properties of the ori
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On Observability and Reconstruction of Promoter Activity Statistics from Reporter Protein Mean and Vpulation averages, the relationship between the observed reporter concentration profile and gene promoter activity is established, and effective methods have been introduced to reconstruct this information from the data. At single-cell level, the relationship between population distribution time pro
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Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathwayse topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods.
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