Titlebook: Human T-Cell Leukemia Virus; Peter K. Vogt Book 1985 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-

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Molecular Biology of Human T-Cell Leukemia Virus Associated with Adult T-Cell Leukemia,is; a number of viral . genes and the corresponding cellular proto-. genes that have been conserved during evolution have been identified (. 1977; . 1982). From the studies of these viruses and protoonc genes, general mechanisms of tumorigenesis have been proposed (. et al. 1981; . 1982). Based on t

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Some Perspectives on the Molecular Mechanism of In Vitro Transformation and In Vivo Leukemogenesis -I, have been obtained from patients with an aggressive form of T-cell malignancy now collectively called adult T-cell leukemia (ATL). In addition, HTLV isolates have been obtained from T-cell variants of hairy cell leukemia (see .-. et al., this volume), called HTLV-II, and from patients with acqui

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Human T-Cell Leukemia/Lymphoma Virus: Studies of Host-Virus Interaction,ith adult T-cell leukemias in Japan (. et al. 1982; . et al. 1982a), West Indies (. et al. 1982; . et al. 1982), southeastern United States (. et al. 1983a), Israel (. et al. 1983), and other areas. Despite the diverse geographical clustering of HTLV-related leukemias and lymphomas, serological stud

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0070-217X ins (gag), for re­ verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar­ ranged in the sequence gag, pol, env from the 5‘ to the 3‘ end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions

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Human T-Cell Leukemia/Lymphoma Viruses (HTLV): A Unique Family of Pathogenic Retroviruses,veral other findings are common at presentation, including lymphadenopathy, hepato- megaly, splenomegaly, cutaneous infiltration with neoplastic T cells, hypercalce- mia (with or without lytic bone lesions), and interstitial pulmonary infiltrates. Characteristically, there is an absence of mediastinal tumor involvement.