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Titlebook: Human Pathogenic Papillomaviruses; Harald Hausen Book 1994 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spr

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https://doi.org/10.1007/978-3-642-78487-3Gynäkologie; Karzinogene; Onkologie; cell; cervix, cancer of; gynecology; infection; infections; oncology; or
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Primer-Directed Sequencing of Human Papillomavirus Types,lected from a variety of lesions. Especially, the observation of a correlation between the development of malignant cervical cancer and the presence of certain types of human papillomavirus (H PV) has spurred an extensive search for possible new types of these viruses (for a review see . 1991).
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Epidemiology of Cervical Human Papillomavirus Infections,rlier, more comprehensive reviews are referred to two excellent summaries by . et al. (1988) and Schneider and . (1992). This update will be restricted to cervical HPV infection and will not include recent advances in the epidemiology of cutaneous HPV types or genital types infecting sites other than the cervix (e.g., aerodigestive tract).
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Molecular Pathogenesis of Cancer of the Cervix and Its Causation by Specific Human Papillomavirus Tt cervical cancer-associated human papillomavirus (HPV) types were cloned and characterized. These DNAs are regularly and frequently found in biopsies obtained from cervical cancer patients throughout the world (. et al. 1983; . et al. 1984).
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Epidermodysplasia Verruciformis: Immunological and Clinical Aspects,ized by disseminated wart-like or pityriasis versicolor (PV)-like lesions and skin cancers. The cases may be familial or sporadic, and the inheritance is believed to be autosomal recessive (. 1978), although single cases of X-linked inheritance have been reported (. et al. 1985).
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Functions of Human Papillomavirus Proteins,ereal warts or condyloma acuminata which only rarely progress to malignancy. The high-risk HPVs include HPV-16 and HPV-18 and these are associated with squamous intraepithelial neoplasias which are potentially precancerous. In the cervix, they are associated with cervical intraepithelial neoplasia,
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Protein Phosphatase 2A and the Regulation of Human Papillomavirus Gene Activity, al. 1991). A minority of cervical intra-epithelial neoplasias, causally associated with the same oncogenic HPV types as cervical cancer, develops into cancer after a long latency period of generally more than 10 years. This strongly suggests that the expression of the HPV E6/E7 genes is necessary b
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Papillomaviruses and Cancer of the Upper Digestive and Respiratory Tracts, at least in part may explain at what level these HPV types interfere with cell cycle control mechanisms. However, viral E6–E7 functions are not sufficient for the development of malignant growth, and the additional modification of host cell genes by chemical factors has been considered to be import
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n has to struggle not only against pressures exerted against him from outside, but also the psychological effects of being repressed and invalidated as a person. For Edwin, who holds his father in exaggerated awe, his father is ‘Fate’ which there is no point in attempting to resist. But even as he e
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