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Titlebook: Human Interferon; Production and Clini Warren R. Stinebring,Paul J. Chapple Book 1978 The Editor(s) (if applicable) and The Author(s), unde

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The Future of Interferon as an Antiviral Drug, infection of rabbit skin (2). It is evident from a review published in 1963 that by then workers from all over the world understood the potential of interferon and were characterizing the parameters of this drug(3).
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Human Interferon: Large Scale Production in Embryo Fibroblast Cultures,ed using leukocyte-derived interferon produced by induction with Sendai virus (8). This system of production is dependent on the supply of human blood buffy coats, and this factor alone restricts expansion of production from present levels.
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New Microcarriers for the Large Scale Production of Anchorage-Dependent Mammalian Cells,sents many difficulties. Since each roller bottle has limited production capability, scale up is achieved by increasing the number of bottles used. This multiplicity of low productivity reactors is physically difficult to manipulate (e.g. for medium changes, or cell harvest) and virtually impossible to maintain in a homogeneous state.
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