| 书目名称 | Human Immunodeficiency Virus Reverse Transcriptase |
| 编辑 | Stuart LeGrice,Matthias Gotte |
| 视频video | |
| 概述 | First comprehensive volume in nearly 20 years Editors have more than 30 years of experience Book will also address the future of Reverse Transcriptase |
| 图书封面 |  |
| 描述 | The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing |
| 出版日期 | Book 2013 |
| 关键词 | DNA Synthesis; HIV/AIDS; Retroviral Therapy; Reverse Transcriptase; infectious diseases |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-7291-9 |
| isbn_softcover | 978-1-4899-9953-5 |
| isbn_ebook | 978-1-4614-7291-9 |
| copyright | Springer Science+Business Media New York 2013 |
发表于 2025-3-21 18:24:23
